Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana

被引：542

作者：

Lin, XY ^{[1
]}

Kaul, SS ^{[1
]}

Rounsley, S ^{[1
]}

Shea, TP ^{[1
]}

Benito, MI ^{[1
]}

Town, CD ^{[1
]}

Fujii, CY ^{[1
]}

Mason, T ^{[1
]}

Bowman, CL ^{[1
]}

Barnstead, M ^{[1
]}

Feldblyum, TV ^{[1
]}

Buell, CR ^{[1
]}

Ketchum, KA ^{[1
]}

Lee, J ^{[1
]}

Ronning, CM ^{[1
]}

Koo, HL ^{[1
]}

Moffat, KS ^{[1
]}

Cronin, LA ^{[1
]}

Shen, M ^{[1
]}

Pai, G ^{[1
]}

Van Aken, S ^{[1
]}

Umayam, L ^{[1
]}

Tallon, LJ ^{[1
]}

Gill, JE ^{[1
]}

Adams, MD ^{[1
]}

Carrera, AJ ^{[1
]}

Creasy, TH ^{[1
]}

Goodman, HM ^{[1
]}

Somerville, CR ^{[1
]}

Copenhaver, GP ^{[1
]}

Preuss, D ^{[1
]}

Nierman, WC ^{[1
]}

White, O ^{[1
]}

Eisen, JA ^{[1
]}

Salzberg, SL ^{[1
]}

Fraser, CM ^{[1
]}

Venter, JC ^{[1
]}

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

来源：

NATURE | 1999年 / 402卷 / 6763期

关键词：

D O I：

10.1038/45471

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130-140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free assemblies (contigs) of 3.6 and 16 megabases (Mb). The latter represents the longest published stretch of uninterrupted DNA sequence assembled from any organism to date. Chromosome 2 represents 15% of the genome and encodes 4,037 genes, 49% of which have no predicted function. Roughly 250 tandem gene duplications were found in addition to large-scale duplications of about 0.5 and 4.5 Mb between chromosomes 2 and 1 and between chromosomes 2 and 4, respectively. Sequencing of nearly 2 Mb within the genetically defined centromere revealed a low density of recognizable genes, and a high density and diverse range of vestigial and presumably inactive mobile elements. More unexpected is what appears to be a recent insertion of a continuous stretch of 75% of the mitochondrial genome into chromosome 2.

引用

页码：761 / +

页数：13

共 50 条

[1] [Anonymous], 1998, NATURE, DOI DOI 10.1038/35140
[2] Bevan M, 1997, PLANT CELL, V9, P476, DOI 10.1105/tpc.9.4.476
[3] PERVASIVE MIGRATION OF ORGANELLAR DNA TO THE NUCLEUS IN PLANTS
BLANCHARD, JL
SCHMIDT, GW
[J]. JOURNAL OF MOLECULAR EVOLUTION, 1995, 41 (04) : 397 - 406
[4] Multiple repetitive DNA sequences in the paracentromeric regions of Arabidopsis thaliana L.
Brandes, A
Thompson, H
Dean, C
HeslopHarrison, JS
[J]. CHROMOSOME RESEARCH, 1997, 5 (04) : 238 - 246
[5] Prediction of complete gene structures in human genomic DNA
Burge, C
Karlin, S
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 268 (01) : 78 - 94
[6] Genome sequence of the nematode C-elegans:: A platform for investigating biology
不详
[J]. SCIENCE, 1998, 282 (5396) : 2012 - 2018
[7] CHARACTERIZATION OF THE CDNA AND PATTERN OF EXPRESSION OF A NEW GENE OVER-EXPRESSED IN HUMAN HEPATOMAS AND COLONIC TUMORS
CHARRASSE, S
MAZEL, M
TAVIAUX, S
BERTA, P
CHOW, T
LARROQUE, C
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 234 (02): : 406 - 413
[8] CONSTRUCTION AND CHARACTERIZATION OF A BACTERIAL ARTIFICIAL CHROMOSOME LIBRARY OF ARABIDOPSIS-THALIANA
CHOI, S
CREELMAN, RA
MULLET, JE
WING, RA
[J]. PLANT MOLECULAR BIOLOGY REPORTER, 1995, 13 (02) : 124 - 128
[9] Computational method to predict mitochondrially imported proteins and their targeting sequences
Claros, MG
Vincens, P
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 241 (03): : 779 - 786
[10] CLAROS MG, 1994, COMPUT APPL BIOSCI, V10, P685

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