Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene

被引：15

作者：

Deng, Y

Madan, A

Banta, AB

Friedman, C

Trask, BJ

Hood, L

Li, LH

机构：

[1] Univ Washington, Div Genet & Dev, Dept Mol Biotechnol, Seattle, WA 98195 USA

[2] Univ Washington, Div Genet & Dev, Stowers Inst Med Res, Seattle, WA 98195 USA

[3] Univ Washington, Div Genet & Dev, Dept Pediat, Seattle, WA 98195 USA

来源：

GENOMICS | 2000年 / 63卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1006/geno.1999.6045

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notch receptors, was determined. The 30-kb DNA sequence spanning the JAG2 gene contains 26 exons and a putative promoter region. Several potential binding sites for transcription factors, including NF-kappa b, E47, E12, E2F, Ets-1, MyoD, and OCT-1, were found in the human JAG2 promoter region. The JAG2 gene was also mapped to the chromosomal region 14q32 using fluorescence in situ hybridization. (C) 2000 Academic Press.

引用

收藏

页码：133 / 138

页数：6

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