What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?

被引：20

作者：

McCulloch, Richard ^{[1
,2
]}

Horn, David ^{[3
]}

机构：

[1] Univ Glasgow, Wellcome Ctr Mol Parasitol, Glasgow G12 8TA, Lanark, Scotland

[2] Glasgow Biomed Res Ctr, Div Infect & Immun, Glasgow G12 8TA, Lanark, Scotland

[3] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

来源：

TRENDS IN PARASITOLOGY | 2009年 / 25卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

TRANSFERRIN-RECEPTOR VARIATION; VARIABLE ANTIGEN REPERTOIRE; GENE-EXPRESSION; BRUCEI-RHODESIENSE; IN-VITRO; EQUIPERDUM; TELOMERES; PARASITE; IDENTIFICATION; RECOMBINATION;

D O I：

10.1016/j.pt.2009.05.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Antigenic variation is crucial for the survival of African trypanosomes in mammals and involves switches in expression of variant surface glycoprotein genes, which are co-transcribed with a number of expression-site-associated genes (ESAGs) from loci termed 'blood-stream expression sites' (BESs). Trypanosomes possess multiple BESs, although the reason for this (and why ESAGs are resident in these loci) has remained a subject of debate. The genome sequence of Trypanosoma brucei, released in 2005, did not include the BESs because of their telomeric disposition. This gap in our knowledge has now been bridged by two new studies, which we discuss here, asking what has been revealed about the biological significance of BES multiplicity and ESAG function and evolution.

引用

页码：359 / 363

页数：5