Lignin peroxidase catalysed oxidation of 4-methoxymandelic acid. The role of mediator structure

被引：21

作者：

Baciocchi, E ^{[1
]}

Gerini, MF ^{[1
]}

Lanzalunga, O ^{[1
]}

Mancinelli, S ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

TETRAHEDRON | 2002年 / 58卷 / 40期

关键词：

lignin peroxidase; mediation; redox potential; radical cation lifetime;

D O I：

10.1016/S0040-4020(02)00997-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A large number of substances have been tested as redox mediators in the UP-catalysed oxidation of 4-methoxymandelic acid (4-MMA) to anisaldehyde. In some cases (i.e. thioanisole), the mediation efficiency is almost equal to the maximum value displayed by the natural mediator veratryl alcohol. The mediation efficiency is a function of the redox potential of the mediator and also appears to depend on the kinetic effectiveness with which the mediator is oxidised by the enzyme. In contrast, the lifetime of the mediator radical cation seems not to play any significant role, which would support the idea that the redox mediation is actually accomplished by a complex between the mediator radical cation and the enzyme. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8087 / 8093

页数：7

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