Chemoenzymatic preparation of optically active β-amino-cyclohexanols and their application in the enantioselective addition of diethylzinc to benzaldehyde

被引：17

作者：

González-Sabín, J ^{[1
]}

Gotor, V ^{[1
]}

Rebolledo, F ^{[1
]}

机构：

[1] Univ Oviedo, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 08期

关键词：

D O I：

10.1016/j.tetasy.2004.03.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Optically active vesamicol and other trans-2-(N,N-dialkylamino)cyclohexanols have been easily prepared in a two step sequence: opening of the oxirane ring of cyclohexene oxide with a secondary amine and subsequent resolution of the resulting racemic amino alcohol by transesterification catalyzed by Pseudomonas ccpacia lipase. The utility of these beta-aminocyclohexanols as chiral ligands in the enantioselective addition of diethylzinc to benzaldehyde has also been investigated. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1335 / 1341

页数：7

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