Chemoenzymatic preparation of optically active β-amino-cyclohexanols and their application in the enantioselective addition of diethylzinc to benzaldehyde

被引:17
作者
González-Sabín, J [1 ]
Gotor, V [1 ]
Rebolledo, F [1 ]
机构
[1] Univ Oviedo, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain
关键词
D O I
10.1016/j.tetasy.2004.03.002
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Optically active vesamicol and other trans-2-(N,N-dialkylamino)cyclohexanols have been easily prepared in a two step sequence: opening of the oxirane ring of cyclohexene oxide with a secondary amine and subsequent resolution of the resulting racemic amino alcohol by transesterification catalyzed by Pseudomonas ccpacia lipase. The utility of these beta-aminocyclohexanols as chiral ligands in the enantioselective addition of diethylzinc to benzaldehyde has also been investigated. (C) 2004 Elsevier Ltd. All rights reserved.
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页码:1335 / 1341
页数:7
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