Efficient ruthenium-catalyzed racemization of secondary alcohols: application to dynamic kinetic resolution

被引：76

作者：

Dijksman, A ^{[1
]}

Elzinga, JM ^{[1
]}

Li, YX ^{[1
]}

Arends, IWCE ^{[1
]}

Sheldon, RA ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, NL-2628 BL Delft, Netherlands

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(02)00187-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three new ruthenium-based catalytic systems are described which are capable of catalyzing the racemization of chiral secondary alcohols. In addition, one of these systems, [TosN(CH2)(2)NH2]RuCl(p-cymene)/TEMPO, was able to catalyze the in Situ racemization during enzymatic resolution, i.e. dynamic kinetic resolution. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：879 / 884

页数：6

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