Nonpeptide glycoprotein IIB/IIIA inhibitors .18. Indole alpha-sulfonamide acids are potent inhibitors of platelet aggregation

被引：15

作者：

Brashear, KM ^{[1
]}

Cook, JJ ^{[1
]}

Bednar, B ^{[1
]}

Bednar, RA ^{[1
]}

Gould, RJ ^{[1
]}

Halczenko, W ^{[1
]}

Holahan, MA ^{[1
]}

Lynch, RJ ^{[1
]}

Hartman, GD ^{[1
]}

Hutchinson, JH ^{[1
]}

机构：

[1] MERCK & CO INC,DEPT PHARMACOL,W POINT,PA 19486

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10085-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationship (SAR) of a series of orally active glycoprotein IIb/IIIa antagonists containing an alkyl or aryl sulfonamide grafted onto an indole core is described. (C) 1997 Elsevier Science Ltd.

引用

页码：2793 / 2798

页数：6

共 30 条

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