Nonpeptide GPIIb/IIIa inhibitors .10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation

被引：45

作者：

Egbertson, MS ^{[1
]}

Hartman, GD ^{[1
]}

Gould, RJ ^{[1
]}

Bednar, B ^{[1
]}

Bednar, RA ^{[1
]}

Cook, JJ ^{[1
]}

Gaul, SL ^{[1
]}

Holahan, MA ^{[1
]}

Libby, LA ^{[1
]}

Lynch, JJ ^{[1
]}

Lynch, RJ ^{[1
]}

Sitko, GR ^{[1
]}

Stranieri, MT ^{[1
]}

Vassallo, LM ^{[1
]}

机构：

[1] MERCK RES LABS,DEPT PHARMACOL,W POINT,PA 19486

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 21期

关键词：

D O I：

10.1016/0960-894X(96)00473-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potency enhancing features of two series of fibrinogen receptor antagonists were combined to give analogs with improved potency and oral activity. Antagonists containing either alkyl or aryl sulfonamides and a central isoindolinone structural constraint demonstrate high affinity for both activated and unactivated platelet receptors. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2519 / 2524

页数：6

共 10 条

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