3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

被引：1774

作者：

Kolesky, David B. ^{[1
]}

Truby, Ryan L. ^{[1
]}

Gladman, A. Sydney ^{[1
]}

Busbee, Travis A. ^{[1
]}

Homan, Kimberly A. ^{[1
]}

Lewis, Jennifer A. ^{[1
]}

机构：

[1] Harvard Univ, Wyss Inst Biol Inspired Engn, Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 19期

基金：

美国国家科学基金会;

关键词：

3D printing; bioprinting; vasculature; tissue engineering; biomaterials; FREEFORM FABRICATION; GELATIN; MORPHOGENESIS; VIABILITY; NETWORKS; PRESSURE;

D O I：

10.1002/adma.201305506

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3124 / 3130

页数：7

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