Ins(1,4,5)P3 metabolism and the family of IP3-3Kinases

被引：57

作者：

Pattni, K ^{[1
]}

Banting, G ^{[1
]}

机构：

[1] Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

CELLULAR SIGNALLING | 2004年 / 16卷 / 06期

关键词：

calcium; calmodulin; inositol; ER; phosphatase; PEST sequences;

D O I：

10.1016/j.cellsig.2003.10.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The release of Ca2+ from intracellular stores is triggered by the second messenger inositol (1,4,5)-trisphosphate (Ins(1,4,5)P-3) The regulation of this process is critically important for cellular homeostasis. Ins(1,4,5)P-3 is rapidly metabolised, either to mositol (1,4)-bisphosphate (Ins(1,4)P-2) by inositol polyphosphate 5-phosphatases or to inositol (1,3,4,5)-tetrakisphosphate (Ins(1,3,4,5)P-4) by one of a family of inositol (1,4,5)P-3 3-kinases (IP3-3Ks). Three isoforms Of IP3-3K have now been identified in mammals; they have a conserved C-terminal catalytic domain, but divergent N-termini. This review discusses the metabolism of Ins(1,4,5)P-3, compares the IP3-3K isofornis and addresses potential mechanisms by which their activity might be regulated. (C) 2003 Elsevier Inc, All rights reserved.

引用

页码：643 / 654

页数：12

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