Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial

被引:152
作者
Gavgani, ASM
Hodjati, MH
Mohite, H
Davies, CR
机构
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[2] Tabriz Univ Med Sci, Tabriz, Iran
关键词
D O I
10.1016/S0140-6736(02)09609-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Deltamethrin-impregnated dog collars reduce sandfly bite rates on dogs, and are effective in killing sandflies that attempt to feed. Because domestic dogs are the principal reservoir hosts of zoonotic visceral leishmaniasis, we tested whether community-wide application of dog collars could protect children against infection with Leishmania infantum, the parasite that causes the disease. Methods 18 villages were paired, matched by preintervention child prevalence of L infantum infection. Within pairs, villages were randomly assigned to either control or intervention. All domestic dogs in intervention villages were provided with collars for the transmission season. The main outcome measure was incidence of L infantum infection after 1 year measured by seroconversion. Secondary outcomes were leishmanin skin test (LST) conversion and seroconversion in dogs. Findings The seroconversion rate in children was 1.49% (17/1141) in the intervention villages and 2.41% (26/1078) in control villages (odds ratio 0.57, 95% Cl 0.36-0.90, p = 0.017). LST conversion was also lowered, but not significantly (odds ratio 0.66, 0.41-1.08, p = 0.096). The seroconversion rate in dogs in intervention villages was also significantly reduced (0.46, 0.30-0.70, p = 0.0003). Interpretation Community-wide application of deltamethrin-impregnated dog collars not only protects domestic dogs from L infantum infections, but might also reduce the risk of L infantum infection in children. These dog collars could have a role in control of visceral leishmaniasis and replace controversial dog culling programmes in some countries. However, the effectiveness of dog collars will depend on the importance of wild versus domestic canids as reservoir hosts of L infantum.
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页码:374 / 379
页数:6
相关论文
共 24 条
[1]  
Alimohammadian MH, 1993, MED J IRAN, V93, P23
[2]   Leishmania and human immunodeficiency virus coinfection: The first 10 years [J].
Alvar, J ;
Canavate, C ;
GutierrezSolar, B ;
Jimenez, M ;
Laguna, F ;
LopezVelez, R ;
Molina, R ;
Moreno, J .
CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (02) :298-+
[3]   Studies on control of visceral leishmaniasis:: Impact of dog control on canine and human visceral leishmaniasis in Jacobina, Bahia, Brazil [J].
Ashford, DA ;
David, JR ;
Freire, M ;
David, R ;
Sherlock, I ;
Eulálio, MD ;
Sampaio, DP ;
Badaro, R .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1998, 59 (01) :53-57
[4]   Leishmaniasis reservoirs and their significance in control [J].
Ashford, RW .
CLINICS IN DERMATOLOGY, 1996, 14 (05) :523-532
[5]  
COURTENAY O, 1998, THESIS LONDON U
[6]   A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (Sao Goncalo do Amaranto, RN) [J].
da Silva, VO ;
Borja-Cabrera, GP ;
Pontes, NNC ;
de Souza, EP ;
Luz, KG ;
Palatnik, M ;
de Sousa, CBP .
VACCINE, 2000, 19 (9-10) :1082-1092
[7]   Age, acquired immunity and the risk of visceral leishmaniasis: a prospective study in Iran [J].
Davies, CR ;
Gavgani, ASM .
PARASITOLOGY, 1999, 119 :247-257
[8]   Leishmaniasis - Public health aspects and control [J].
Desjeux, P .
CLINICS IN DERMATOLOGY, 1996, 14 (05) :417-423
[9]   Effect of eliminating seropositive canines on the transmission of visceral leishmaniasis in Brazil [J].
Dietze, R ;
Barros, GB ;
Teixeira, L ;
Harris, J ;
Michelson, K ;
Falqueto, A ;
Corey, R .
CLINICAL INFECTIOUS DISEASES, 1997, 25 (05) :1240-1242
[10]   The logic of visceral leishmaniasis control [J].
Dye, C .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1996, 55 (02) :125-130