Impact of ovarian stimulation on corpus luteum function and embryonic implantation

被引：92

作者：

Tavaniotou, A ^{[1
]}

Albano, C ^{[1
]}

Smitz, J ^{[1
]}

Devroey, P ^{[1
]}

机构：

[1] Free Univ Brussels, Ctr Reprod Med, B-1090 Brussels, Belgium

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2002年 / 55卷 / 1-2期

关键词：

corpus luteum; endometrial biopsy; ovarian stimulation; luteinizing hormone; luteal phase; in-vitro fertilization; gonadotrophin-releasing hormone;

D O I：

10.1016/S0165-0378(01)00134-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The luteal phase has been found to be defective in virtually all the stimulation protocols used in in-vitro fertilization (IVF), indicating that common mechanisms might be involved despite the use of different drugs. A normal luteal phase is characterised by a normal hormonal environment, normal progesterone secretion by the corpus luteum and adequate endometrial secretory transformation. Luteinizing hormone supports the corpus luteum and luteal luteinizing hormone (LH) levels have been found to be reduced in human menopausal gonadotrophin (HMG), gonadotrophin-releasing hormone (GnRH)-agonist/HMG and GnRH-antagonist/HMG protocols, probably leading to an insufficient corpus luteum function. Supraphysiological steroid serum concentrations routinely observed in stimulated cycles may adversely affect LH secretion and induce a luteal-phase defect. In turn, these high steroid serum concentrations may advance early luteal-phase endometrial development leading to embryo-endometrial asynchrony and decreased pregnancy rates in IVF cycles. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：123 / 130

页数：8

共 28 条

[11] Dominant expression and distribution of oestrogen receptor β over oestrogen receptor α in the human corpus luteum [J].

Hosokawa, K ;

Ottander, U ;

Wahlberg, P ;

Ny, T ;

Cajander, S ;

Olofsson, IJ .

MOLECULAR HUMAN REPRODUCTION, 2001, 7 (02) :137-145

[12] Expression of gap junction protein connexin-43 in the human and baboon (Papio anubis) corpus luteum [J].

KhanDawood, FS ;

Yang, J ;

Dawood, MY .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (02) :835-842

[13]

MESSINIS IE, 1987, J REPROD FERTIL, V79, P549

[14] GONADOTROPIN-RELEASING-HORMONE RECEPTOR GENE-EXPRESSION IN HUMAN OVARY AND GRANULOSA-LUTEIN CELLS [J].

MINARETZIS, D ;

JAKUBOWSKI, M ;

MORTOLA, JF ;

PAVLOU, SN .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (02) :430-434

[15] Expression of oestrogen receptor α and β mRNA in corpus luteum of human subjects [J].

Misao, R ;

Nakanishi, Y ;

Sun, WS ;

Fujimoto, J ;

Iwagaki, S ;

Hirose, R ;

Tamaya, T .

MOLECULAR HUMAN REPRODUCTION, 1999, 5 (01) :17-21

[16] SUPPRESSION OF SERUM LEVELS OF LUTEINIZING-HORMONE BY SHORT-LOOP AND LONG-LOOP NEGATIVE FEEDBACK IN OVARIECTOMIZED WOMEN [J].

MIYAKE, A ;

AONO, T ;

KINUGASA, T ;

TANIZAWA, O ;

KURACHI, K .

JOURNAL OF ENDOCRINOLOGY, 1979, 80 (03) :353-356

[17] Endometrial pinopodes indicate a shift in the window of receptivity in IVF cycles [J].

Nikas, G ;

Develioglu, OH ;

Toner, JP ;

Jones, HW .

HUMAN REPRODUCTION, 1999, 14 (03) :787-792

[18] THE ROLES OF ESTRADIOL AND PROGESTERONE IN DECREASING LUTEINIZING-HORMONE PULSE FREQUENCY IN THE LUTEAL PHASE OF THE MENSTRUAL-CYCLE [J].

NIPPOLDT, TB ;

REAME, NE ;

KELCH, RP ;

MARSHALL, JC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (01) :67-76

[19] DATING THE ENDOMETRIAL BIOPSY [J].

NOYES, RW ;

HERTIG, AT ;

ROCK, J .

FERTILITY AND STERILITY, 1950, 1 (01) :3-25

[20] TRIAL OF SUPPORT TREATMENT WITH HUMAN CHORIONIC-GONADOTROPIN IN THE LUTEAL PHASE AFTER TREATMENT WITH BUSERELIN AND HUMAN MENOPAUSAL GONADOTROPIN IN WOMEN TAKING PART IN AN INVITRO FERTILIZATION PROGRAM [J].

SMITH, EM ;

ANTHONY, FW ;

GADD, SC ;

MASSON, GM .

BRITISH MEDICAL JOURNAL, 1989, 298 (6686) :1483-1486

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