The involvement of the transcription factor Yin Yang 1 in cancer development and progression

被引：120

作者：

Castellano, Giancarlo ^{[2
]}

Torrisi, Elena ^{[1
]}

Ligresti, Giovanni ^{[1
]}

Malaponte, Grazia ^{[1
]}

Militello, Loredana ^{[1
]}

Russo, Alessia E. ^{[1
]}

McCubrey, James A. ^{[3
]}

Canevari, Silvana ^{[2
]}

Libra, Massimo ^{[1
]}

机构：

[1] Univ Catania, Dept Biomed Sci, I-95124 Catania, Italy

[2] Ist Nazl Tumori, Fdn IRCCS, Dept Expt Oncol, Unit Mol Therapies, I-20133 Milan, Italy

[3] E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Greenville, NC USA

来源：

CELL CYCLE | 2009年 / 8卷 / 09期

关键词：

Yin Yang 1; transcription factor; cancer development; drug resistance; tumor progression; prognostic factor; GENE-EXPRESSION PROFILES; RETRACTED ARTICLE. SEE; UP-REGULATION; MEDIATED APOPTOSIS; FACTOR YIN-YANG-1; MESSENGER-RNA; NITRIC-OXIDE; TRAIL; YY1; INHIBITION;

D O I：

10.4161/cc.8.9.8314

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Yin Yang 1 (YY1) transcription factor has a pivotal role in normal biological processes such as development, differentiation, replication and cell proliferation exerting its effects on a huge number of genes involved in these processes. Mechanisms of YY1 action are related to its ability to initiate, activate, or repress transcription depending upon the context in which it binds. The role of YY1 played in cancer has been recently explored. This article summarizes the most relevant studies focused on YY1 regulation and dwells on the way how its overexpression may affect the clinical behavior of several cancer types. Furthermore, the contribution of the upregulation of YY1 exerted in response to therapeutic-induced apoptosis is discussed.

引用

页码：1367 / 1372

页数：6

共 54 条

[1]

Allouche A., 2008, BREAST CANCER RES, V10, P9

[2] Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status [J].

Andersson, A. ;

Ritz, C. ;

Lindgren, D. ;

Eden, P. ;

Lassen, C. ;

Heldrup, J. ;

Olofsson, T. ;

Rade, J. ;

Fontes, M. ;

Porwit-MacDonald, A. ;

Behrendtz, M. ;

Hoglund, M. ;

Johansson, B. ;

Fioretos, T. .

LEUKEMIA, 2007, 21 (06) :1198-1203

[3] RETRACTED: Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells (Retracted Article. See vol 197, pg 4860, 2016) [J].

Baritaki, Stavroula ;

Suzuki, Eriko ;

Umezawa, Kazuo ;

Spandidos, Demetrios A. ;

Berenson, James ;

Daniels, Tracy R. ;

Penichet, Manuel L. ;

Jazirehi, Ali R. ;

Palladino, Michael ;

Bonavida, Benjamin .

JOURNAL OF IMMUNOLOGY, 2008, 180 (09) :6199-6210

[4] RETRACTED: Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase, inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation (Retracted Article. See vol 197, pg 4859, 2016) [J].

Baritaki, Stavroula ;

Katsman, Alina ;

Chatterjee, Devasis ;

Yeung, Kam C. ;

Spandidos, Demetrios A. ;

Bonavida, Benjamin .

JOURNAL OF IMMUNOLOGY, 2007, 179 (08) :5441-5453

[5]

Baritaki S, 2007, INT J ONCOL, V31, P69

[6] Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1 [J].

Baritaki, Stavroula ;

Huerta-Yepez, Sara ;

Sakai, Toshiyuki ;

Spandidos, Demetrios A. ;

Bonavida, Benjamin .

MOLECULAR CANCER THERAPEUTICS, 2007, 6 (04) :1387-1399

[7] Reverse engineering of regulatory networks in human B cells [J].

Basso, K ;

Margolin, AA ;

Stolovitzky, G ;

Klein, U ;

Dalla-Favera, R ;

Califano, A .

NATURE GENETICS, 2005, 37 (04) :382-390

[8] Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers [J].

Berchuck, A ;

Iversen, ES ;

Lancaster, JM ;

Pittman, J ;

Luo, JQ ;

Lee, P ;

Murphy, S ;

Dressman, HK ;

Febbo, PG ;

West, M ;

Nevins, JR ;

Marks, JR .

CLINICAL CANCER RESEARCH, 2005, 11 (10) :3686-3696

[9] Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses [J].

Bhattacharjee, A ;

Richards, WG ;

Staunton, J ;

Li, C ;

Monti, S ;

Vasa, P ;

Ladd, C ;

Beheshti, J ;

Bueno, R ;

Gillette, M ;

Loda, M ;

Weber, G ;

Mark, EJ ;

Lander, ES ;

Wong, W ;

Johnson, BE ;

Golub, TR ;

Sugarbaker, DJ ;

Meyerson, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13790-13795

[10] Regulation of p53 The next generation [J].

Blattner, Christine .

CELL CYCLE, 2008, 7 (20) :3149-3153

← 1 2 3 4 5 6 →