Molecular mechanism of monoamine toxicity in Parkinson's disease: hypothetical cell death model

被引：7

作者：

del Rio, MJ ^{[1
]}

Velez-Pardo, C ^{[1
]}

机构：

[1] Univ Antioquia, Sch Med, Medellin, Colombia

来源：

MEDICAL HYPOTHESES | 2000年 / 54卷 / 02期

关键词：

D O I：

10.1054/mehy.1999.0839

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Although there have been experimental approaches to understanding the etiology of Parkinson's disease, the cause of cell degeneration in this neurological disorder remains a mystery. Herein, a hypothetical model is proposed to explain the mechanism leading neurons to die. The model is based on recent experimental evidence and it attempts to dissect the actions of dopamine and metal ions as potential triggers for the activation of an ordered cascade of events of the cell death machinery. (C) 2000 Harcourt Publishers Ltd.

引用

页码：269 / 274

页数：6

共 79 条

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