Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis

被引：220

作者：

Paul, C

Wolkenstein, P

Adle, H

Wechsler, J

Garchon, HJ

Revuz, J

Roujeau, JC

机构：

[1] HOP HENRI MONDOR,DEPT DERMATOL,F-94010 CRETEIL,FRANCE

[2] HOP NECKER ENFANTS MALAD,INSERM,U25,PARIS,FRANCE

[3] HOP HENRI MONDOR,DEPT PATHOL,F-94010 CRETEIL,FRANCE

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1996年 / 134卷 / 04期

关键词：

D O I：

10.1111/j.1365-2133.1996.tb06976.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening diseases characterized by extensive epidermal destruction. The aim of our study was to investigate apoptosis in keratinocytes of patients with TEN and TEN/SJS overlap syndrome. Keratinocytes from TEN patients were found to undergo extensive apoptosis. These results suggest that cell destruction in TEN occurs as a result of apoptosis, Our findings suggest that apoptosis inhibitory agents may play an important part in the therapeutic strategy of TEN.

引用

页码：710 / 714

页数：5

共 17 条

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