Human papillomaviruses and cancer

被引:91
作者
Haedicke, Juliane [1 ]
Iftner, Thomas [1 ]
机构
[1] Univ Tubingen Hosp, Div Expt Virol, D-72076 Tubingen, Germany
关键词
Papillomaviruses; Oropharyngeal; Nonmelanoma; Tonsillar; E6; Alpha-HPV; Beta-HPV; HPV vaccine; CERVICAL INTRAEPITHELIAL NEOPLASIA; CUTANEOUS HUMAN PAPILLOMAVIRUSES; SQUAMOUS-CELL CARCINOMAS; NONMELANOMA SKIN CANCERS; E6; PROTEINS; ADENOVIRUS E4-ORF1; RNA EXPRESSION; MESSENGER-RNA; E7; PROTEIN; LOW-RISK;
D O I
10.1016/j.radonc.2013.06.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Human papillomaviruses (HPV) are small oncogenic DNA viruses of which more than 200 types have been identified to date. A small subset of these is etiologically linked to the development of anogenital malignancies such as cervical cancer. In addition, recent studies established a causative relationship between these high-risk HPV types and tonsillar and oropharyngeal cancer. Clinical management of cervical cancer and head and neck squamous cell carcinomas (HNSCCs) is largely standardized and involves surgical removal of the tumor tissue as well as adjuvant chemoradiation therapy. Notably, the response to therapeutic intervention of HPV-positive HNSCCs has been found to be better as compared to HPV-negative tumors. Although the existing HPV vaccine is solely licensed for the prevention of cervical cancer, it might also have prophylactic potential for the development of high-risk HPV-associated HNSCCs. Another group of viruses, which belongs to the beta-HPV subgroup, has been implicated in nonmelanoma skin cancer, however, the etiology remains to be established. Treatment of HPV-induced nonmelanoma skin cancer is based on local excision. However, topically applied immune-modulating substances represent non-surgical alternatives for the management of smaller cutaneous tumors. In this review we present the current knowledge of the role of HPV in cancer development and discuss clinical management options as well as targets for the development of future intervention therapies. (C) 2013 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 108 (2013) 397-402
引用
收藏
页码:397 / 402
页数:6
相关论文
共 86 条
[71]   Entry of Human Papillomavirus Type 16 by Actin-Dependent, Clathrin- and Lipid Raft-Independent Endocytosis [J].
Schelhaas, Mario ;
Shah, Bhavin ;
Holzer, Michael ;
Blattmann, Peter ;
Kuehling, Lena ;
Day, Patricia M. ;
Schiller, John T. ;
Helenius, Ari .
PLOS PATHOGENS, 2012, 8 (04)
[72]   Classification of weakly carcinogenic human papillomavirus types: Addressing the limits of epidemiology at the borderline [J].
Schiffman M. ;
Clifford G. ;
Buonaguro F.M. .
Infectious Agents and Cancer, 4 (1)
[73]   COMPARISON OF THE PROPERTIES OF THE E6-GENE AND E7-GENE OF LOW-RISK AND HIGH-RISK CUTANEOUS PAPILLOMAVIRUSES REVEALS STRONGLY TRANSFORMING AND HIGH RB-BINDING ACTIVITY FOR THE E7-PROTEIN OF THE LOW-RISK HUMAN PAPILLOMAVIRUS TYPE-1 [J].
SCHMITT, A ;
HARRY, JB ;
RAPP, B ;
WETTSTEIN, FO ;
IFTNER, T .
JOURNAL OF VIROLOGY, 1994, 68 (11) :7051-7059
[74]   Etiologic Role of Human Papillomavirus Infection in Bladder Carcinoma [J].
Shigehara, Kazuyoshi ;
Sasagawa, Toshiyuki ;
Kawaguchi, Shohei ;
Nakashima, Takao ;
Shimamura, Masayoshi ;
Maeda, Yuji ;
Konaka, Hiroyuki ;
Mizokami, Atsushi ;
Koh, Eitetsu ;
Namiki, Mikio .
CANCER, 2011, 117 (10) :2067-2076
[75]   Detection of Immunoglobulin G against E7 of Human Papillomavirus in Non-Small-Cell Lung Cancer [J].
Storey, Raul ;
Joh, Joongho ;
Kwon, Amy ;
Jenson, A. Bennett ;
Ghim, Shin-je ;
Kloecker, Goetz H. .
JOURNAL OF ONCOLOGY, 2013, 2013
[76]   THE PATHOGENESIS OF THE RABBIT PAPILLOMA-TO-CARCINOMA SEQUENCE [J].
SYVERTON, JT .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1952, 54 (06) :1126-1140
[77]   Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types [J].
Thomas, M ;
Banks, L .
JOURNAL OF GENERAL VIROLOGY, 1999, 80 :1513-1517
[78]   Inhibition of Bak-induced apoptosis by HPV-18 E6 [J].
Thomas, M ;
Banks, L .
ONCOGENE, 1998, 17 (23) :2943-2954
[79]   E6 Proteins from Multiple Human Betapapillomavirus Types Degrade Bak and Protect Keratinocytes from Apoptosis after UVB Irradiation [J].
Underbrink, Michael P. ;
Howie, Heather L. ;
Bedard, Kristin M. ;
Koop, Jennifer I. ;
Galloway, Denise A. .
JOURNAL OF VIROLOGY, 2008, 82 (21) :10408-10417
[80]   High-Risk Human Papillomavirus-Positive Lung Cancer Molecular Evidence for a Pattern of Pulmonary Metastasis [J].
van Boerdonk, Robert A. A. ;
Daniels, Johannes M. A. ;
Bloemena, Elisabeth ;
Krijgsman, Oscar ;
Steenbergen, Renske D. M. ;
Brakenhoff, Ruud H. ;
Grunberg, Katrien ;
Ylstra, Bauke ;
Meijer, Chris J. L. M. ;
Smit, Egbert F. ;
Snijders, Peter J. F. ;
Heideman, Danielle A. M. .
JOURNAL OF THORACIC ONCOLOGY, 2013, 8 (06) :711-718