Enantioselective addition of diketene to aldehydes promoted by chiral Schiff base-titanium alkoxide complex. Application to asymmetric synthesis of potential inhibitors of HMG coenzyme reductase

被引：23

作者：

Hayashi, M ^{[1
]}

Yoshimoto, K

Hirata, N

Tanaka, K

Oguni, N

Harada, K

Matsushita, A

Kawachi, Y

Sasaki, H

机构：

[1] Kobe Univ, Fac Sci, Dept Chem, Kobe, Hyogo 6578501, Japan

[2] Yamaguchi Univ, Fac Sci, Dept Chem, Yamaguchi 7538512, Japan

[3] Ube Ind Ltd, Res Lab, Corp Res & Dev, Ube, Yamaguchi 7558633, Japan

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2001年 / 41卷 / 04期

关键词：

D O I：

10.1092/PX53-Y9JJ-FU8V-GKEN

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly enantioselective addition of diketene to aldehydes was achieved by using novel Schiff base-titanium alkoxide complexes. Up to 92% ee of 5-hydroxy3-oxoesters was obtained. This procedure provides an efficient method for the asymmetric synthesis of potential inhibitors of HMG coenzyme reductase.

引用

页码：241 / 246

页数：6

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