Elevation of striatal interleukin-6 and serum corticosterone contents in MPTP-treated mice

被引：22

作者：

Kaku, K ^{[1
]}

Shikimi, T ^{[1
]}

Kamisaki, Y ^{[1
]}

Shinozuka, K ^{[1
]}

Ishino, H ^{[1
]}

Okunishi, H ^{[1
]}

Takaori, S ^{[1
]}

机构：

[1] Shimane Med Univ, Dept Psychiat, Izumo, Shimane 6938501, Japan

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1999年 / 26卷 / 09期

关键词：

corticosterone; interleukin-1; beta; interleukin-6; MPTP; striatum;

D O I：

10.1046/j.1440-1681.1999.03113.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Changes in the content of striatal interleukins (IL-1 beta and IL-6) and serum corticosterone in relation to deterioration of the dopaminergic system induced by 1-methyl-1-phenyl-2,2,3,6-tetrahydropyridine (MPTP; a dopaminergic neurotoxin; 20 mg/kg i.p., four administrations/12 h) in C57BL/6J mice were investigated, 2. Striatal dopamine, IL-1 beta, IL-6 and serum corticosterone were measured on days 1 and 7 post-MPTP. 3, Dopamine depletion was more severe on day 7 than on day 1 post-treatment. 4. Increases in IL-6 were observed on days 1 and 7 post-MPTP. The increase in striatal IL-6 content varied with the extent of dopamine depletion, although the IL-1 beta concentration remained unchanged compared with control values on days 1 and 7 post-treatment. 5. Serum corticosterone was not different from control on day 1 post-MPTP. However. marked increases in the serum corticosterone were observed on day 7 post-treatment. 6, These results suggest that changes in striatal IL-6 and serum corticosterone are closely associated with the severity of MPTP-induced dopaminergic degeneration.

引用

页码：680 / 683

页数：4

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