Kowalski ester homologation.: Application to the synthesis β-amino esters

被引：34

作者：

Gray, D ^{[1
]}

Concellón, C ^{[1
]}

Gallagher, T ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 14期

关键词：

D O I：

10.1021/jo049562h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Kowalski ester homologation protocol has been applied to a representative range of alpha-amino esters to provide beta-amino esters with excellent levels of enantio- and diastereocontrol. A key feature of this chemistry is the nature of the N-protecting group that is employed.

引用

页码：4849 / 4851

页数：3

共 45 条

[1]

Abele S, 2000, EUR J ORG CHEM, V2000, P1

[2] LITHIUM N-BENZYLTRIMETHYLSILYLAMIDE (LSA) - A NEW REAGENT FOR CONJUGATE ADDITION ENOLATE TRAPPING REACTIONS [J].