Cdk5: mediator of neuronal death and survival

被引：74

作者：

Cheung, ZH ^{[1
]}

Ip, NY ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2004年 / 361卷 / 1-3期

关键词：

p35; p39; apoptosis; Alzheimer's disease; neuronal survival; ErbB receptor; NMDA receptor;

D O I：

10.1016/j.neulet.2003.12.117

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cdk5 (cyclin-dependent kinase 5) is a serine/threonine kinase implicated to play pivotal roles in neuronal development. Recently, its potential involvement as a regulator of neuronal death and survival has attracted considerable interests. Importantly, increasing evidence has linked Cdk5 to the etiopathology of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. Here we summarize the recent findings on Cdk5 not only as an important participant in neuronal death, but also a key player in neuronal survival. Elucidating the mechanisms of regulation of Cdk5 and its downstream signaling might prove to be crucial in the therapeutic treatment of neurodegenerative diseases. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：47 / 51

页数：5

共 51 条

[11] Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation [J].

Kerokoski, P ;

Suuronen, T ;

Salminen, A ;

Soininen, H ;

Pirttilä, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 298 (05) :693-698

[12] The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis [J].

Kerokoski, P ;

Suuronen, T ;

Salminen, A ;

Soininen, H ;

Pirttilä, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (04) :998-1002

[13]

Ko J, 2001, J NEUROSCI, V21, P6758

[14] Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25 [J].

Kusakawa, G ;

Saito, T ;

Onuki, R ;

Ishiguro, K ;

Kishimoto, T ;

Hisanaga, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (22) :17166-17172

[15] Central synapse and neuromuscular junction: same players, different roles [J].

Lai, KO ;

Ip, NY .

TRENDS IN GENETICS, 2003, 19 (07) :395-402

[16] Neurotoxicity induces cleavage of p35 to p25 by calpain [J].

Lee, MS ;

Kwon, YT ;

Li, MW ;

Peng, JM ;

Friedlander, RM ;

Tsai, LH .

NATURE, 2000, 405 (6784) :360-364

[17]

LEW J, 1992, J BIOL CHEM, V267, P25922

[18]

LEW J, 1992, J BIOL CHEM, V267, P13383

[19] A BRAIN-SPECIFIC ACTIVATOR OF CYCLIN-DEPENDENT KINASE-5 [J].

LEW, J ;

HUANG, QQ ;

QI, Z ;

WINKFEIN, RJ ;

AEBERSOLD, R ;

HUNT, T ;

WANG, JH .

NATURE, 1994, 371 (6496) :423-426

[20] Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3 [J].

Li, BS ;

Zhang, L ;

Takahashi, S ;

Ma, W ;

Jaffe, H ;

Kulkarni, AB ;

Pant, HC .

EMBO JOURNAL, 2002, 21 (03) :324-333

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