The total synthesis of UK-1

被引：79

作者：

DeLuca, MR ^{[1
]}

Kerwin, SM ^{[1
]}

机构：

[1] UNIV TEXAS,COLL PHARM,DIV MED CHEM,AUSTIN,TX 78712

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(96)02288-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise, five-step total synthesis of UK-1, a novel bis(benzoxazole) metabolite of Streptomyces sp. 517-02, was accomplished. The methyl ether of UK-1 was also synthesized in 3 steps using the same methodology. Both syntheses are accomplished by the sequential construction of two benzoxazole rings derived from 3-hydroxyanthranilic acid. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：199 / 202

页数：4

共 6 条

[1] MOLECULAR RECOGNITION BETWEEN LIGANDS AND NUCLEIC-ACIDS - NOVEL PYRIDINE-CONTAINING AND BENZOXAZOLE-CONTAINING AGENTS RELATED TO HOECHST-33258 THAT EXHIBIT ALTERED DNA-SEQUENCE SPECIFICITY DEDUCED FROM FOOTPRINTING ANALYSIS AND SPECTROSCOPIC STUDIES [J].