Hypermethylation pathways to colorectal cancer - Implications for prevention and detection

被引：16

作者：

Herman, JG ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2002年 / 31卷 / 04期

关键词：

D O I：

10.1016/S0889-8553(02)00058-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Epigenetic changes play an important role in the development and progression of colorectal cancer. The best characterized of these changes is the promoter region methylation of CpG islands of genes that play key roles in this disease. These changes compliment and lead to genetic changes that are well established as central to colorectal cancer progression. They may also prove useful in molecular detection approaches.

引用

页码：945 / +

页数：15

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