Hypermethylation pathways to colorectal cancer - Implications for prevention and detection

被引：16

作者：

Herman, JG ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2002年 / 31卷 / 04期

关键词：

D O I：

10.1016/S0889-8553(02)00058-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Epigenetic changes play an important role in the development and progression of colorectal cancer. The best characterized of these changes is the promoter region methylation of CpG islands of genes that play key roles in this disease. These changes compliment and lead to genetic changes that are well established as central to colorectal cancer progression. They may also prove useful in molecular detection approaches.

引用

页码：945 / +

页数：15

共 81 条

[41] A CELL-CYCLE REGULATOR POTENTIALLY INVOLVED IN GENESIS OF MANY TUMOR TYPES [J].

KAMB, A ;

GRUIS, NA ;

WEAVERFELDHAUS, J ;

LIU, QY ;

HARSHMAN, K ;

TAVTIGIAN, SV ;

STOCKERT, E ;

DAY, RS ;

JOHNSON, BE ;

SKOLNICK, MH .

SCIENCE, 1994, 264 (5157) :436-440

[42]

Kane MF, 1997, CANCER RES, V57, P808

[43] Lessons from hereditary colorectal cancer [J].

Kinzler, KW ;

Vogelstein, B .

CELL, 1996, 87 (02) :159-170

[44] Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers [J].

Kuismanen, SA ;

Holmberg, MT ;

Salovaara, R ;

Schweizer, P ;

Aaltonen, LA ;

de la Chapelle, A ;

Nyström-Lahti, M ;

Peltomäki, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12661-12666

[45] SUPPRESSION OF INTESTINAL NEOPLASIA BY DNA HYPOMETHYLATION [J].

LAIRD, PW ;

JACKSONGRUSBY, L ;

FAZELI, A ;

DICKINSON, SL ;

JUNG, WE ;

LI, E ;

WEINBERG, RA ;

JAENISCH, R .

CELL, 1995, 81 (02) :197-205

[46] Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis [J].

Lecomte, T ;

Berger, A ;

Zinzindohoué, F ;

Micard, S ;

Landi, B ;

Blons, H ;

Beaune, P ;

Cugnenc, PH ;

Laurent-Puig, P .

INTERNATIONAL JOURNAL OF CANCER, 2002, 100 (05) :542-548

[47] Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation [J].

Lee, PJ ;

Washer, LL ;

Law, DJ ;

Boland, CR ;

Horon, IL ;

Feinberg, AP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10366-10370

[48] Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: Association with DNA replication error and shorter survival [J].

Liang, JT ;

Chang, KJ ;

Chen, JC ;

Lee, CC ;

Cheng, YM ;

Hsu, HC ;

Wu, MS ;

Wang, SM ;

Lin, JT ;

Cheng, AL .

ONCOLOGY, 1999, 57 (02) :149-156

[49] INACTIVATION OF THE TYPE-II TGF-BETA RECEPTOR IN COLON-CANCER CELLS WITH MICROSATELLITE INSTABILITY [J].

MARKOWITZ, S ;

WANG, J ;

MYEROFF, L ;

PARSONS, R ;

SUN, LZ ;

LUTTERBAUGH, J ;

FAN, RS ;

ZBOROWSKA, E ;

KINZLER, KW ;

VOGELSTEIN, B ;

BRATTAIN, M ;

WILLSON, JKV .

SCIENCE, 1995, 268 (5215) :1336-1338

[50] 5' CPG ISLAND METHYLATION IS ASSOCIATED WITH TRANSCRIPTIONAL SILENCING OF THE TUMOR-SUPPRESSOR P16/CDKN2/MTS1 IN HUMAN CANCERS [J].

MERLO, A ;

HERMAN, JG ;

MAO, L ;

LEE, DJ ;

GABRIELSON, E ;

BURGER, PC ;

BAYLIN, SB ;

SIDRANSKY, D .

NATURE MEDICINE, 1995, 1 (07) :686-692

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