Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice

被引：15

作者：

Zhang, Xi-ping ^{[1
]}

Feng, Guang-hua ^{[1
]}

Zhang, Jie ^{[2
]}

Cai, Yang ^{[1
]}

Tian, Hua ^{[3
]}

Zhang, Xiao-feng ^{[4
]}

Zhou, Yi-feng ^{[4
]}

Wang, Zhi-wei ^{[5
]}

Wang, Ke-yi ^{[5
]}

机构：

[1] Hangzhou First Peoples Hosp, Dept Gen Surg, Hangzhou 310006, Peoples R China

[2] Zhejiang Univ Tradit Chinese Med, Coll Clin Med 1, Hangzhou 310053, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gen Surg, Hangzhou 310009, Peoples R China

[4] Hangzhou First Peoples Hosp, Dept Digest, Hangzhou 310006, Peoples R China

[5] Hangzhou First Peoples Hosp, Centralab, Hangzhou 310006, Peoples R China

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2009年 / 10卷 / 03期

关键词：

Salvia miltiorrhizae; Traditional Chinese medicine; Severe acute pancreatitis (SAP); Obstructive jaundice (OJ); Heart; BACTERIAL TRANSLOCATION; PHOSPHOLIPASE A(2); ORGAN FAILURE; INJURY; MECHANISM; GLUTAMINE;

D O I：

10.1631/jzus.B0820179

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the therapeutic effects and mechanisms of Salvia miltiorrhizae (Danshen) in the treatment of severe acute pancreatitis (SAP)- or obstructive jaundice (OJ)-induced heart injury. A total of 288 rats were used for SAP- (n=108) and OJ-associated (n=180) experiments. The rats were randomly divided into sham-operated, model control, and Salvia miltiorrhizae-treated groups. According to the difference of time points after operation, SAP rats in each group were subdivided into 3, 6 and 12 h subgroups (n=12), whereas OJ rats were subdivided into 7, 14, 21, and 28 d subgroups (n=15). At the corresponding time points after operation, the mortality rates of the rats, the contents of endotoxin and phospholipase A(2) (PLA(2)) in blood, and pathological changes of the hearts were investigated. The numbers of dead SAP and OJ rats in the treated groups declined as compared with those in the model control group, but not significantly (P > 0.05). The contents of endotoxin (at 6 and 12 h in SAP rats and on 7, 14, 21, and 28 d in OJ rats, respectively) and PLA(2) (at 6 and 12 h in SAP rats and on 28 d in OJ rats, respectively) in the treated group were significantly lower than those in the model control group (P < 0.01 and P < 0.001, respectively). Besides, myocardial pathological injuries were mitigated in SAP and OJ rats. In this study, we found that Salvia miltiorrhizae improved myocardial pathological changes, reduced the content of PLA(2) in blood, and decreased the mortality rates of SAP and OJ rats, exerting protective effects on the hearts of the rats.

引用

页码：193 / 202

页数：10

共 38 条

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