Azimuthal directional sensitivity of prepulse inhibition of the pinna startle reflex in decerebrate rats

Previous studies have indicated that the auditory midbrain, the inferior colliculus, is important for both sound localization and mediation of prepulse inhibition of the startle reflex. The present study investigated the azimuthal directional sensitivity of prepulse inhibition of the pinna startle reflex in decerebrate rats. The pinna startle reflex was measured by recording multi-unit action potentials from the cervicoauricular muscles. The startling noise burst (94 dB SPL) was produced by a stationary speaker at 0 degrees azimuth, and the non-startling prepulse noise burst (46 dB SPL) was produced by a movable speaker whose direction was changed in the frontal azimuthal plane. The interval between the onset of the prepulse sound and the onset of the startling sound was 100 ms. The pinna reflex to the startling sound was strongly inhibited by the prepulse sound, and the inhibited startle response exhibited a flat azimuthal directional curve. In addition to further confirming that the neural pathways mediating prepulse inhibition are located in the brainstem, the present results indicate that interaural disparities of binaural inputs used for sound localization are not capable of modulating prepulse inhibition of the startle reflex. (C) 2000 Elsevier Science Inc.