Coronary artery calcium, exercise tolerance, and CHD events in asymptomatic men

被引:27
作者
LaMonte, Michael J.
FitzGerald, Shannon J.
Levine, Benjamin D.
Church, Timothy S.
Kampert, James B.
Nichaman, Milton Z.
Gibbons, Larry W.
Blair, Steven N.
机构
[1] Cooper Inst, Dallas, TX 75230 USA
[2] Cooper Clin, Dallas, TX USA
[3] Presbyterian Med Ctr, Inst Esercise & Environm Med, Dallas, TX USA
[4] Univ Texas, SW Med Ctr, Dallas, TX USA
关键词
coronary heart disease; coronary calcium; electron beam tomography; exercise testing; primary prevention; cardiovascular fitness; BEAM COMPUTED-TOMOGRAPHY; HEART-DISEASE; CARDIORESPIRATORY FITNESS; MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; AMERICAN-COLLEGE; RANDOMIZED-TRIAL; PROGNOSTIC VALUE; MORTALITY;
D O I
10.1016/j.atherosclerosis.2005.12.014
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Coronary artery calcium (CAC) scores >= 100 are predictive of CHD events in asymptomatic men. Exercise tolerance of >= 10METs predicts lower event rates in CHD patients; however, its relationship with events in individuals with subclinical atherosclerosis is less known. Participants were 710 asymptomatic men from the Aerobics Center Longitudinal Study whose exercise tolerance (ET) was quantified (< 10 or > 10METs) and whose CAC score was >= 100 as measured by electron beam tomography. During 3.5 years of follow-up 59 CHD events occurred. The age-adjusted hazard ratio (HR) of CHD events was 0.26 (95% CI=0.15-0.45) in men whose ET was > 10METs compared with men whose ET was < 10 METs. Adjustment for CHD risk factors and abnormal exercise ECG did not change the association between ET and CHD. The extent of underlying atherosclerosis did not influence the association between ET and CHD; for example, the HR for CHD events in the >= 10MET group among men with CAC scores < 400 and >= 400 was 0.16 (95% CI = 0.05-0.56) and 0.23 (95% CI = 0.11-0.46), respectively. In asymptomatic men with subclinical. coronary atherosclerosis, an ET of >= 10 METs identifies patients at lower risk for manifest CHD. (c) 2005 Elsevier. Ireland Ltd. All rights reserved.
引用
收藏
页码:157 / 162
页数:6
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