OPINION Challenges in circulating tumour cell research

被引：855

作者：

Alix-Panabieres, Catherine ^{[1
,2
]}

Pantel, Klaus ^{[3
]}

机构：

[1] Univ Med Ctr, Lab Rare Human Circulating Cells, Dept Cellular & Tissular Biopathol Tumors, Saint Eloi Hosp,Inst Med Regenerat & Biotherapy, F-34295 Montpellier 5, France

[2] Univ Inst Clin Res, Epidemiol Biostat & Publ Hlth UM1 EA2415, F-34093 Montpellier 5, France

[3] Univ Med Ctr, Dept Tumor Biol, D-20246 Hamburg, Germany

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 09期

基金：

欧洲研究理事会;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; METASTATIC BREAST-CANCER; RESISTANT PROSTATE-CANCER; POLYMERASE-CHAIN-REACTION; PERIPHERAL-BLOOD; CLINICAL-SIGNIFICANCE; BIOLOGICAL INSIGHTS; CHEMOKINE RECEPTORS; PROGENITOR CELLS; LIQUID BIOPSY;

D O I：

10.1038/nrc3820

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the past ten years, circulating tumour cells (CTCs) have received enormous attention as new biomarkers and the subject of basic research. Although CTCs are already used in numerous clinical trials, their clinical utility is still under investigation. Many issues regarding the detection and characterization of CTCs remain unknown. In this Opinion article, we propose a conceptual framework of CTC assays and point out current challenges of CTC research, which might structure this dynamic field of translational cancer research.

引用

页码：623 / 631

页数：9

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