Direct conductance measurements of short single DNA molecules in dry conditions

被引：42

作者：

Dulic, Diana ^{[1
]}

Tuukkanen, Sampo ^{[1
]}

Chung, Chia-Ling ^{[1
]}

Isambert, Antoine ^{[1
]}

Lavie, Pascal ^{[1
]}

Filoramo, Arianna ^{[1
]}

机构：

[1] CEA, IRAMIS, CNRS,URA 2464, Serv Phys Etat Condense,Lab Elect Mol, F-91191 Gif Sur Yvette, France

来源：

NANOTECHNOLOGY | 2009年 / 20卷 / 11期

关键词：

PHOTOINDUCED ELECTRON-TRANSFER; CHARGE-TRANSPORT; LAMBDA-DNA; JUNCTIONS; CONTACTS; DISTANCE; ALKANEDITHIOLS; CONDUCTIVITY; RESISTANCE; MECHANISM;

D O I：

10.1088/0957-4484/20/11/115502

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We present a study of electronic transport in short (12-base-pair) DNA duplexes covalently bonded (via thiol groups) to two gold electrodes obtained by a mechanically controllable break junction (MCJB) technique in dry conditions. A large number of DNA junctions have been repeatedly formed in order to obtain a conductance histogram that reveals a peak which corresponds to the conductance of a single DNA molecule. We observed that the conductivity of a DNA increases upon increasing the content of G: C base pairs in the duplex. With our method we are able to obtain a reliable value of a single DNA conductance and subsequently measure its current-voltage (I-V) characteristics. In contrast to the electronic transport measurements performed with long DNA sequences (hundreds of base pairs) where the obtained conductance values vary a lot with environmental conditions, our values obtained for the short DNA sequences are consistent with the values reported for comparable sequences in aqueous solution.

引用

页数：7