Asymmetric synthesis of (+)-indatraline using rhodium-catalyzed C-H activation

被引：65

作者：

Davies, HML ^{[1
]}

Gregg, TM ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 28期

基金：

美国国家卫生研究院;

关键词：

indatraline; dopamine transporter; CH activation; rhodium carbene; C-H insertion;

D O I：

10.1016/S0040-4039(02)00941-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The potent monoamine reuptake inhibitor (+)-indatraline, 1, was prepared in greater than 98%, cc employing a highly enantioselective carbenoid C-H insertion reaction into 1,4-cyclohexadiene catalyzed by the chiral rhodium complex. Rh-2(S-DOSP)(4). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：4951 / 4953

页数：3

共 19 条

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[9] Catalytic asymmetric synthesis of diarylacetates and 4,4-diarylbutanoates. A formal asymmetric synthesis of (+)-sertraline
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[10] DAVIES HML, 2002, IN PRESS TETRAHEDRON

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