Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

被引：198

作者：

Clayton, David G. ^{[1
]}

机构：

[1] Univ Cambridge, Juvenile Diabet Res Fdn, Wellcome Trust Diabet & Inflammat Lab, Dept Med Genet,Cambridge Inst Med Res, Cambridge, England

来源：

PLOS GENETICS | 2009年 / 5卷 / 07期

基金：

英国惠康基金;

关键词：

RISK; SUSCEPTIBILITY; EPISTASIS; MODELS; ASSOCIATION; FRAMEWORK; SYNERGISM; MELLITUS; DESIGNS; TRAITS;

D O I：

10.1371/journal.pgen.1000540

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

[No abstract available]

引用

页数：6

共 47 条

[11] Gene-environment interactions for complex traits:: definitions, methodological requirements and challenges [J].

Dempfle, Astrid ;

Scherag, Andre ;

Hein, Rebecca ;

Beckmann, Lars ;

Chang-Claude, Jenny ;

Schaefer, Helmut .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2008, 16 (10) :1164-1172

[12]

Elston RC, 1999, STAT MED, V18, P741, DOI 10.1002/(SICI)1097-0258(19990330)18:6<741::AID-SIM64>3.0.CO

[13]

2-U

[14]

EPSTEIN FH, 1968, B NEW YORK ACAD MED, V44, P916

[15]

Fisher R. A., 1919, Transactions of the Royal Society of Edinburgh, V52

[16] MAXIMUM-ENTROPY FOR HYPOTHESIS FORMULATION, ESPECIALLY FOR MULTIDIMENSIONAL CONTINGENCY-TABLES [J].

GOOD, IJ .

ANNALS OF MATHEMATICAL STATISTICS, 1963, 34 (03) :911-+

[17] Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes [J].

Hermann, R ;

Lipponen, K ;

Kiviniemi, M ;

Kakko, T ;

Veijola, R ;

Simell, O ;

Knip, M ;

Ilonen, J .

DIABETOLOGIA, 2006, 49 (06) :1198-1208

[18] MINIMUM SAMPLE-SIZE ESTIMATION TO DETECT GENE ENVIRONMENT INTERACTION IN CASE-CONTROL DESIGNS [J].

HWANG, SJ ;

BEATY, TH ;

LIANG, KY ;

CORESH, J ;

KHOURY, MJ .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 140 (11) :1029-1037

[19] Interpretation of Genetic Association Studies: Markers with Replicated Highly Significant Odds Ratios May Be Poor Classifiers [J].

Jakobsdottir, Johanna ;

Gorin, Michael B. ;

Conley, Yvette P. ;

Ferrell, Robert E. ;

Weeks, Daniel E. .

PLOS GENETICS, 2009, 5 (02)

[20] Genome-based prediction of common diseases: advances and prospects [J].

Janssens, A. Cecile J. W. ;

van Duijn, Cornelia M. .

HUMAN MOLECULAR GENETICS, 2008, 17 :R166-R173

← 1 2 3 4 5 →