Effect of linoleic acid on proliferation and gene expression in the breast cancer cell line T47D

被引：46

作者：

Reyes, N ^{[1
]}

Reyes, I ^{[1
]}

Tiwari, R ^{[1
]}

Geliebter, J ^{[1
]}

机构：

[1] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA

来源：

CANCER LETTERS | 2004年 / 209卷 / 01期

关键词：

linoleic acid; breast cancer; microarray;

D O I：

10.1016/j.canlet.2003.12.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human and animal studies have linked n-6 polyunsaturated fatty acids with mammary carcinogenesis. We investigated the cellular and molecular effects of linoleic acid on the human breast cancer cell line T47D. Linoleic acid had a stimulatory effect on the growth of T47D cells, associated with an increase in the proportion of cells in the S phase of the cell cycle. Microarray, functional group and quantitative PCR analyses indicate that linoleic acid may affect T47D cell growth by modulation of the estrogen receptor (ERalpha), the G13alpha G protein, and p38 MAP kinase gene expression as well genes involved in RNA transcription and cell cycle regulation. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：25 / 35

页数：11

共 44 条

[1] Breast cancer:: from estrogen to androgen receptor [J].

Andò, S ;

De Amicis, F ;

Rago, V ;

Carpino, A ;

Maggiolini, M ;

Panno, ML ;

Lanzino, M .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2002, 193 (1-2) :121-128

[2] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[3] MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance [J].

Atanaskova, N ;

Keshamouni, VG ;

Krueger, JS ;

Schwartz, JA ;

Miller, F ;

Reddy, KB .

ONCOGENE, 2002, 21 (25) :4000-4008

[4] ROLE OF GTP-BINDING PROTEINS IN THE POLYUNSATURATED FATTY-ACID STIMULATED PROLIFERATION OF MOUSE MAMMARY EPITHELIAL-CELLS [J].

BANDYOPADHYAY, GK ;

IMAGAWA, W ;

NANDI, S .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1995, 52 (2-3) :151-158

[5] Metabolic conversion and growth effects of n-6 and n-3 polyunsaturated fatty acids in the T47D breast cancer cell line [J].

Bardon, S ;

Le, MT ;

Alessandri, JM .

CANCER LETTERS, 1996, 99 (01) :51-58

[6] Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers [J].

Bartsch, H ;

Nair, J ;

Owen, RW .

CARCINOGENESIS, 1999, 20 (12) :2209-2218

[7]

BOYD NF, 2003, BRIT J CANCER, V89, P162

[8] Hypoxia and oxidative stress in breast cancer - Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer [J].

Brown, NS ;

Bicknell, R .

BREAST CANCER RESEARCH, 2001, 3 (05) :323-327

[9] PROGESTIN-INDUCED FATTY-ACID SYNTHETASE IN HUMAN MAMMARY-TUMORS - FROM MOLECULAR TO CLINICAL-STUDIES [J].

CHALBOS, D ;

JOYEUX, C ;

GALTIER, F ;

ROCHEFORT, H .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 43 (1-3) :223-228

[10] Similarities of prostate and breast cancer: Evolution, diet, and estrogens [J].

Coffey, DS .

UROLOGY, 2001, 57 (4A) :31-38

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