Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia

被引：4

作者：

Mikhal'chik, E. V. ^{[1
]}

Titkova, S. M.

Anurov, M. V.

Ettinger, A. P.

Korkina, L. G.

机构：

[1] Russian State Med Univ, Dept Mol Biol, Moscow 117437, Russia

[2] Russian State Med Univ, Dept Physiol, Moscow 117437, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 06期

关键词：

burns; lipopolysaccharide; chemiluminescence; antioxidants;

D O I：

10.1007/s10517-006-0253-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content increased in the lungs and epidermis. The preparation of alpha-tocopherol, selenium aspartate, and ubiquinone abolished the effect of lipopolysaccharide, but did not modulate the increase in chemiluminescence under the influence of this agent.

引用

页码：688 / 690

页数：3

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