Preparation of optically active alpha-hydroxy esters: Stereoselective reduction of alpha-keto esters using thermophilic actinomycetes

被引：15

作者：

Ishihara, K

Nishitani, M

Yamaguchi, H

Nakajima, N

Ohshima, T

Nakamura, K

机构：

[1] OKAYAMA PREFECTURAL UNIV,DEPT NUTR SCI,SOJA,OKAYAMA 71911,JAPAN

[2] KYOTO UNIV,INST CHEM RES,UJI,KYOTO 611,JAPAN

来源：

JOURNAL OF FERMENTATION AND BIOENGINEERING | 1997年 / 84卷 / 03期

关键词：

keto ester; stereoselective reduction; thermophile; actinomycetes; immobilization;

D O I：

10.1016/S0922-338X(97)82068-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The asymmetric reduction of alpha-keto esters carried out using actinomycete as a biocatalyst. Ethyl-3-methyl-2-oxobutanoate and methyl benzoylformate were reduced to the corresponding (R)-alcohols with high optical purities, The conversion ratios of alpha-keto esters to the corresponding alpha-hydroxy esters using thermophilic actinomycetes were increased by addition of glycerol into the reaction mixture as an additive. Production of optically pure alpha-hydroxy esters has been achieved by the repetitive use of a Ca2+-alginate-immobilized cells of a thermophilic actinomycete, Pseudonocardia thermophila IFO 12133.

引用

页码：268 / 270

页数：3

共 25 条

[1]

CUSK R, 1991, CHEM REV, V91, P49

[2]

Ditullio D, 1994, Bioorg Med Chem, V2, P415, DOI 10.1016/0968-0896(94)80009-X

[3] ASYMMETRIC SYNTHESIS - ASYMMETRIC HOMOGENEOUS HYDROGENATION CATALYST WHICH BREEDS ITS OWN CHIRALITY [J].