A novel face specific Mannich closure providing access to the saframycin-ecteinascidin series of piperazine based alkaloids

被引：41

作者：

Zhou, BS

Guo, JS

Danishefsky, SJ

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

[2] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10024 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 13期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)00106-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Mannich-like closure of 10-->6 directly provides the backbone stereochemistry required for the titled alkaloids, in contrast to the stereochemical outcome in a related earlier case (3-->4). (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2043 / 2046

页数：4

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TETRAHEDRON LETTERS, 2000, 41 (13) :2039-2042

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