Multicomponent magnetic nanorods for biomolecular separations

被引：169

作者：

Lee, KB

Park, S

Mirkin, CA

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Inst Nanotechnol, Evanston, IL 60208 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 23期

关键词：

magnetic properties; nanostructures; nickel; proteins;

D O I：

10.1002/anie.200454088

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold and nickel are the components of nanorods used to separate biomolecules. The rods can act as a high-surface-area scaffolding for biospecific recognition events in a variety of bioseparation schemes. The magnetic Ni block not only provides specificity with respect to His-tagged proteins but also allows one to conveniently remove rods from a solution by using a magnetic field (see scheme).

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收藏

页码：3048 / 3050

页数：3

相关论文

共 23 条

[1]

ALBERTS B, 2002, MOL BIOL CELL, V3, P483

[2] Selective functionalization of two-component magnetic nanowires [J].

Bauer, LA ;

Reich, DH ;

Meyer, GJ .

LANGMUIR, 2003, 19 (17) :7043-7048

[3] Semiconductor nanocrystals as fluorescent biological labels [J].

Bruchez, M ;

Moronne, M ;

Gin, P ;

Weiss, S ;

Alivisatos, AP .

SCIENCE, 1998, 281 (5385) :2013-2016

[4] Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection [J].

Cao, YWC ;

Jin, RC ;

Mirkin, CA .

SCIENCE, 2002, 297 (5586) :1536-1540

[5] Preferential end-to-end assembly of gold nanorods by biotin-streptavidin connectors [J].

Caswell, KK ;

Wilson, JN ;

Bunz, UHF ;

Murphy, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (46) :13914-13915

[6] Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species [J].

Cui, Y ;

Wei, QQ ;

Park, HK ;

Lieber, CM .

SCIENCE, 2001, 293 (5533) :1289-1292

[7] Using biofunctional magnetic nanoparticles to capture vancomycin-resistant enterococci and other gram-positive bacteria at ultralow concentration [J].

Gu, HW ;

Ho, PL ;

Tsang, KWT ;

Wang, L ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (51) :15702-15703

[8] Cell manipulation using magnetic nanowires [J].

Hultgren, A ;

Tanase, M ;

Chen, CS ;

Meyer, GJ ;

Reich, DH .

JOURNAL OF APPLIED PHYSICS, 2003, 93 (10) :7554-7556

[9] Striped metal nanowires as building blocks and optical tags [J].

Keating, CD ;

Natan, MJ .

ADVANCED MATERIALS, 2003, 15 (05) :451-454

[10] Protein nanoarrays generated by dip-pen nanolithography [J].

Lee, KB ;

Park, SJ ;

Mirkin, CA ;

Smith, JC ;

Mrksich, M .

SCIENCE, 2002, 295 (5560) :1702-1705