Multicomponent magnetic nanorods for biomolecular separations

被引：169

作者：

Lee, KB

Park, S

Mirkin, CA

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Inst Nanotechnol, Evanston, IL 60208 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 23期

关键词：

magnetic properties; nanostructures; nickel; proteins;

D O I：

10.1002/anie.200454088

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold and nickel are the components of nanorods used to separate biomolecules. The rods can act as a high-surface-area scaffolding for biospecific recognition events in a variety of bioseparation schemes. The magnetic Ni block not only provides specificity with respect to His-tagged proteins but also allows one to conveniently remove rods from a solution by using a magnetic field (see scheme).

引用

收藏

页码：3048 / 3050

页数：3

相关论文

共 23 条

[11] FABRICATION AND IMAGING OF 2-DIMENSIONAL PATTERNS OF PROTEINS ADSORBED ON SELF-ASSEMBLED MONOLAYERS BY SCANNING ELECTRON-MICROSCOPY [J].

LOPEZ, GP ;

BIEBUYCK, HA ;

HARTER, R ;

KUMAR, A ;

WHITESIDES, GM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (23) :10774-10781

[12] NANOMATERIALS - A MEMBRANE-BASED SYNTHETIC APPROACH [J].

MARTIN, CR .

SCIENCE, 1994, 266 (5193) :1961-1966

[13]

Nam J.M., 2004, ANGEW CHEM, V116, P1266

[14] Bioactive protein nanoarrays on nickel oxide surfaces formed by dip-pen nanolithography [J].

Nam, JM ;

Han, SW ;

Lee, KB ;

Liu, XG ;

Ratner, MA ;

Mirkin, CA .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (10) :1246-1249

[15] Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins [J].

Nam, JM ;

Thaxton, CS ;

Mirkin, CA .

SCIENCE, 2003, 301 (5641) :1884-1886

[16] Submicrometer metallic barcodes [J].

Nicewarner-Peña, SR ;

Freeman, RG ;

Reiss, BD ;

He, L ;

Peña, DJ ;

Walton, ID ;

Cromer, R ;

Keating, CD ;

Natan, MJ .

SCIENCE, 2001, 294 (5540) :137-141

[17] Self-assembly of mesoscopic metal-polymer amphiphiles [J].

Park, S ;

Lim, JH ;

Chung, SW ;

Mirkin, CA .

SCIENCE, 2004, 303 (5656) :348-351

[18]

Park SJ, 2002, SCIENCE, V295, P1503, DOI 10.1126/science.1067003

[19] Nanoparticles for bioanalysis [J].

Penn, SG ;

He, L ;

Natan, MJ .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (05) :609-615

[20] Electrochemical synthesis and optical readout of striped metal rods with submicron features [J].

Reiss, BD ;

Freeman, RG ;

Walton, ID ;

Norton, SM ;

Smith, PC ;

Stonas, WG ;

Keating, CD ;

Natan, MJ .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2002, 522 (01) :95-103