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Dynamics of intercellular communication during melanoma development

被引：89
作者：
Li, G [1 ]
Herlyn, M
机构：
[1] Univ Penn, Sch Med, Cell & Mol Biol Program, Philadelphia, PA 19104 USA
[2] Wistar Inst Anat & Biol, Tumor Biol Program, Philadelphia, PA 19104 USA
来源：
MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 04期
关键词：
D O I：
10.1016/S1357-4310(00)01692-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Melanoma development involves processes determined collectively by various microenvironmental factors, among which intercellular communication has drawn increased attention. Cell-cell crosstalk mediated by cadherins and connexins results in coordinated regulation of cell growth, differentiation, apoptosis and migration. Abnormal expression of adhesion receptors and dysregulated intercellular communication appears to drive tumor development and progression.
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收藏
页码：163 / 169
页数：7
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