Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens

被引：51

作者：

Bassoli, Angela ^{[1
]}

Borgonova, Gigliola ^{[1
]}

Caimi, Sara ^{[1
]}

Scaglioni, Leonardo ^{[1
]}

Morini, Gabriella ^{[2
]}

Moriello, Aniello Schiano ^{[3
]}

Di Marzo, Vincenzo ^{[4
]}

De Petrocellis, Luciano ^{[3
]}

机构：

[1] Univ Milan, Dipartimento Sci Mol Agroaliment, DISMA, I-20133 Milan, Italy

[2] Univ Gastronom Sci, Pollenzo, CN, Italy

[3] CNR, Ist Cibernet Eduardo Caianiello, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy

[4] CNR, Ist Chim Biomol, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 04期

关键词：

Taste; Chemesthesis; Channel; TRP; COVALENT MODIFICATION; CHANNELS; ACTIVATE; PRODUCTS; KETONES; PLANT;

D O I：

10.1016/j.bmc.2008.12.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Perilla frutescens is a food plant widely used in Asian cuisine. This plant was investigated for its interesting taste and somatosensory properties. Perillaldehyde and perillaketone are among the components of the aromatic extracts from P. Frutescens. These compounds were shown here to activate the cloned TRPA1 channel when expressed in an heterologous cell system and are therefore suggested to be responsible for the chemesthetic properties of this plant. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1636 / 1639

页数：4