Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

被引：37

作者：

Akyol, Sumeyya ^{[1
,2
]}

Ugurcu, Veli ^{[3
]}

Altuntas, Aynur ^{[4
]}

Hasgul, Rukiye ^{[1
]}

Cakmak, Ozlem ^{[5
]}

Akyol, Omer ^{[6
,7
]}

机构：

[1] Turgut Ozal Univ, Vocat Sch Hlth Sci, Div Med Lab Tech, TR-06370 Ankara, Turkey

[2] Gaziosmanpasa Univ, Fac Med, Dept Biochem, Tokat, Turkey

[3] Private Bilecik Orhangazi Dialysis Ctr, Bilecik, Turkey

[4] Council Forens Med, Ankara Branch, Ankara, Turkey

[5] Gazi Univ, Fac Educ, Dept Biol, Ankara, Turkey

[6] Hacettepe Univ, Fac Med, Dept Med Biochem, Ankara, Turkey

[7] Council Forens Med, Ankara Branch, Div Chem, Ankara, Turkey

来源：

SCIENTIFIC WORLD JOURNAL | 2014年

关键词：

ISCHEMIA-REPERFUSION INJURY; ACUTE-RENAL-FAILURE; VANCOMYCIN-INDUCED NEPHROTOXICITY; GENTAMICIN-INDUCED NEPHROTOXICITY; NITRIC-OXIDE; RAT KIDNEYS; IN-VIVO; ELECTROMAGNETIC-RADIATION; PREFERENTIAL CYTOTOXICITY; MYOCARDIAL-ISCHEMIA;

D O I：

10.1155/2014/561971

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.

引用

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