In vivo study indicating loss of intracortical inhibition in tumor-associated epilepsy

被引：14

作者：

Irlbacher, K ^{[1
]}

Brandt, SA ^{[1
]}

Meyer, BU ^{[1
]}

机构：

[1] Humboldt Univ, Charite, Klinikum,Dept Neurol, Unit Motor Disturbances & Cortex Funct, D-13353 Berlin, Germany

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 01期

关键词：

D O I：

10.1002/ana.10229

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transcranial magnetic stimulation was performed in 2 patients with focal motor seizures in the right hand caused by a circumscribed tumor process affecting the left precentral gyrus. In both cases, paired-pulse transcranial magnetic stimulation showed a loss of intracortical inhibition for interstimulus intervals of 2 to 4msec that was replaced by an enormous facilitation in the lesioned hand motor cortex. The uniform impairment of inhibitory mechanisms in epileptogenic tumors with different histologies suggests a common, nonspecific cause of tumor-related epileptogenesis.

引用

页码：119 / 122

页数：4

共 11 条

[1] The pathogenesis of tumour associated epilepsy [J].

Beaumont, A ;

Whittle, IR .

ACTA NEUROCHIRURGICA, 2000, 142 (01) :1-15

[2] Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex [J].

Di Lazzaro, V ;

Oliviero, A ;

Meglio, M ;

Cioni, B ;

Tamburrini, G ;

Tonali, P ;

Rothwell, JC .

CLINICAL NEUROPHYSIOLOGY, 2000, 111 (05) :794-799

[3] CORTICOCORTICAL INHIBITION IN HUMAN MOTOR CORTEX [J].

KUJIRAI, T ;

CARAMIA, MD ;

ROTHWELL, JC ;

DAY, BL ;

THOMPSON, PD ;

FERBERT, A ;

WROE, S ;

ASSELMAN, P ;

MARSDEN, CD .

JOURNAL OF PHYSIOLOGY-LONDON, 1993, 471 :501-519

[4]

MEYER B, 2001, CLIN NEUROPHYSIOL, V112, pS7

[5]

NAKAMURA Y, 2000, CLIN NEUROPHYSIOL, V111, pS24

[6]

Siebner HR, 1998, MUSCLE NERVE, V21, P1209, DOI 10.1002/(SICI)1097-4598(199809)21:9<1209::AID-MUS15>3.3.CO

[7]

2-O

[8] Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans [J].

Werhahn, KJ ;

Kunesch, E ;

Noachtar, S ;

Benecke, R ;

Classen, J .

JOURNAL OF PHYSIOLOGY-LONDON, 1999, 517 (02) :591-597

[9] Localization of the motor hand area to a knob on the precentral gyrus - A new landmark [J].

Yousry, TA ;

Schmid, UD ;

Alkadhi, H ;

Schmidt, D ;

Peraud, A ;

Buettner, A ;

Winkler, P .

BRAIN, 1997, 120 :141-157

[10] Dextromethorphan decreases the excitability of the human motor cortex [J].

Ziemann, U ;

Chen, R ;

Cohen, LG ;

Hallett, M .

NEUROLOGY, 1998, 51 (05) :1320-1324

← 1 2 →