In vivo study indicating loss of intracortical inhibition in tumor-associated epilepsy

被引：14

作者：

Irlbacher, K ^{[1
]}

Brandt, SA ^{[1
]}

Meyer, BU ^{[1
]}

机构：

[1] Humboldt Univ, Charite, Klinikum,Dept Neurol, Unit Motor Disturbances & Cortex Funct, D-13353 Berlin, Germany

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 01期

关键词：

D O I：

10.1002/ana.10229

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transcranial magnetic stimulation was performed in 2 patients with focal motor seizures in the right hand caused by a circumscribed tumor process affecting the left precentral gyrus. In both cases, paired-pulse transcranial magnetic stimulation showed a loss of intracortical inhibition for interstimulus intervals of 2 to 4msec that was replaced by an enormous facilitation in the lesioned hand motor cortex. The uniform impairment of inhibitory mechanisms in epileptogenic tumors with different histologies suggests a common, nonspecific cause of tumor-related epileptogenesis.

引用

页码：119 / 122

页数：4