Impact of Anesthetic Regimen on Remote Ischemic Preconditioning in the Rat Heart In Vivo

被引：52

作者：

Behmenburg, Friederike ^{[1
]}

van Caster, Patrick ^{[1
]}

Bunte, Sebastian ^{[1
]}

Brandenburger, Timo ^{[1
]}

Heinen, Andre ^{[2
]}

Hollmann, Markus W. ^{[3
]}

Huhn, Ragnar ^{[1
]}

机构：

[1] Univ Hosp Duesseldorf, Dept Anesthesiol, Moorenstr 5, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ Duesseldorf, Inst Cardiovasc Physiol, Dusseldorf, Germany

[3] Univ Amsterdam, Acad Med Ctr, Lab Expt Intens Care & Anesthesiol, Dept Anesthesiol, Amsterdam, Netherlands

来源：

ANESTHESIA AND ANALGESIA | 2018年 / 126卷 / 04期

关键词：

SURGERY; CARDIOPROTECTION; INJURY; PROTECTION; KINASE;

D O I：

10.1213/ANE.0000000000002563

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Remote ischemic preconditioning (RIPC) seems to be a promising cardioprotective strategy with contradictive clinical data suggesting the anesthetic regimen influencing the favorable impact of RIPC. This study aimed to investigate whether cardio protection by RIPC is abolished by anesthetic regimens. Male Wistar rats were randomized to 6 groups. Anesthesia was either maintained by pentobarbital (Pento) alone or a combination of sevoflurane (Sevo) and remifentanil or propofol (Prop) and remifentanil in combination with and without RIPC. RIPC reduced infarct size in Pento- and Sevo-anesthetized rats (Pento-RIPC: 30% +/- 9% versus Pento-control [Con]: 65% +/- 6%, P < .001; Sevo-RIPC: 31% +/- 6% versus Sevo-Con: 61% +/- 8%, P < .001), but RIPC did not initiate cardio protection in Prop-anesthetized animals (Prop-RIPC: 59% +/- 6% versus Prop-Con: 59% +/- 8%, P = 1.000). Cardio protection by RIPC is abolished by Prop.

引用

页码：1377 / 1380

页数：4

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