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Polygenic control of human T lymphotropic virus type I (HTLV-I) provirus load and the risk of HTLV-I-associated myelopathy/tropical spastic paraparesis

被引：70
作者：
Vine, AM
Witkover, AD
Lloyd, AL
Jeffery, KJM
Siddiqui, A
Marshall, SEF
Bunce, M
Eiraku, N
Izumo, S
Usuku, K
Osame, M
Bangham, CRM
机构：
[1] Imperial Coll Fac Med, Dept Immunol, London W2 1PG, England
[2] Churchill Hosp, Oxford Transplant Ctr, Oxford OX3 7LJ, England
[3] Inst Adv Study, Program Theoret Biol, Princeton, NJ 08540 USA
[4] Kagoshima Univ, Dept Internal Med 3, Kagoshima 890, Japan
[5] Kagoshima Univ, Dept Med Informat, Kagoshima 890, Japan
来源：
JOURNAL OF INFECTIOUS DISEASES | 2002年 / 186卷 / 07期
基金：
英国惠康基金;
关键词：
D O I：
10.1086/342953
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is one outcome of infection with HTLV-I. A population association study of 229 patients with HAM/TSP and 202 healthy carriers of HTLV-I in southern Japan showed that this outcome of HTLV-I infection and the HTLV-I provirus load are under polygenic control. Of 58 polymorphic sites studied in 39 non-HLA candidate gene loci, 3 new host genetic factors that influenced the risk of HAM/TSP or the provirus load of HTLV-I were identified. The promoter TNF-863A allele predisposed to HAM/TSP, whereas SDF-1 +801A 3'UTR, and IL-15 191C alleles conferred protection. Knowledge of HTLV-I-infected individuals' ages, sex, provirus load, HTLV-I subgroup, and genotypes at the loci HLA-A, HLA-C, SDF-1, and TNF-alpha allowed for the correct identification of 88% of cases of HAM/TSP in this Japanese cohort.
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收藏
页码：932 / 939
页数：8
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