Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development

被引：59

作者：

Dan, I

Watanabe, NM

Kobayashi, T

Yamashita-Suzuki, K

Fukagaya, Y

Kajikawa, E

Kimura, WK

Nakashima, TM

Matsumoto, K

Ninomiya-Tsuji, J

Kusumi, A

机构：

[1] JST, ERATO, Kusumi Membrane Organizer Project, Nagoya, Aichi 4600012, Japan

[2] Nagoya Univ, Grad Sch Sci, Dept Biol Sci, Nagoya, Aichi, Japan

[3] JST, CREST, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

FEBS LETTERS | 2000年 / 469卷 / 01期

关键词：

misshapen/NIKs-related kinase; signal transduction; germinal center kinase family kinase; mitogen-activated protein kinase; stress-activated protein kinase;

D O I：

10.1016/S0014-5793(00)01247-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways. (C) 2000 Federation of European Biochemical Societies.

引用

页码：19 / 23

页数：5

共 23 条

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