Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity

被引：116

作者：

Bang, OY

Hong, HS

Kim, DH

Kim, H

Boo, JH

Huh, K ^{[1
]}

Mook-Jung, I

机构：

[1] Ajou Univ, Dept Neurol, Coll Med, Suwon 441749, South Korea

[2] Ajou Univ, Brain Dis Res Ctr, Coll Med, Suwon 442721, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Biochem, Inst Canc Res, Seoul 110799, South Korea

来源：

NEUROBIOLOGY OF DISEASE | 2004年 / 16卷 / 01期

关键词：

estrogen; genistein; beta amyloid; Alzheimer's disease; cell death; estrogen receptor;

D O I：

10.1016/j.nbd.2003.12.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen. In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) beta-agonist, with those of estrogen. Genistein and 17beta-estradiol showed comparable levels of protection against Abeta-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17beta-estradiol, but not genistein, induced proliferation of uterine endometrial cells. Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：21 / 28

页数：8

共 39 条

[31]

Ravnikar V A, 1992, Womens Health Issues, V2, P75, DOI 10.1016/S1049-3867(05)80275-0

[32]

Shughrue PJ, 1997, J COMP NEUROL, V388, P507, DOI 10.1002/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO

[33]

2-6

[34]

SMALL GW, 1995, AM J PSYCHIAT, V152, P1757

[35] THE NATURAL TYROSINE KINASE INHIBITOR GENISTEIN PRODUCES CELL-CYCLE ARREST AND APOPTOSIS IN JURKAT T-LEUKEMIA CELLS [J].

SPINOZZI, F ;

PAGLIACCI, MC ;

MIGLIORATI, G ;

MORACA, R ;

GRIGNANI, F ;

RICCARDI, C ;

NICOLETTI, I .

LEUKEMIA RESEARCH, 1994, 18 (06) :431-439

[36] β-Estradiol attenuate amyloid β-peptide toxicity via nicotinic receptors [J].

Svensson, AL ;

Nordberg, A .

NEUROREPORT, 1999, 10 (17) :3485-3489

[37] Estrogen therapy in postmenopausal women - Effects on cognitive function and dementia [J].

Yaffe, K ;

Sawaya, G ;

Lieberburg, I ;

Grady, D .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (09) :688-695

[38] Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro [J].

Zava, DT ;

Duwe, G .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1997, 27 (01) :31-40

[39] Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons [J].

Zhao, LX ;

Chen, Q ;

Brinton, RD .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2002, 227 (07) :509-519

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