Two cases of thiopurine methyltransferase (TPMT) deficiency - a lucky save and a near miss with azathioprine

被引：23

作者：

Gardiner, Sharon J.

Gearry, Richard B.

Barclay, Murray L.

Begg, Evan J.

机构：

[1] Christchurch Hosp, Dept Clin Pharmacol, Christchurch, New Zealand

[2] Christchurch Hosp, Dept Med, Christchurch, New Zealand

[3] Christchurch Hosp, Dept Gastroenterol, Christchurch, New Zealand

[4] Christchurch Sch Med, Christchurch, New Zealand

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2006年 / 62卷 / 04期

关键词：

azathioprine; pancytopenia; pharmacogenetics; thiopurine methyltransferase;

D O I：

10.1111/j.1365-2125.2005.02474.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background The association between thiopurine methyltransferase (TPMT) deficiency and myelosuppression with azathioprine is well recognized. Two cases are presented that illustrate the very different outcomes that may occur with azathioprine in patients with TPMT deficiency, which affects 0.3-0.6% of caucasians. Case 1 The first patient's TPMT deficiency was identified following hospitalization for pancytopenia attributed to azathioprine. Case 2 The second patient was identified as deficient early in treatment and myelosuppression was avoided by treating with a greatly decreased dose (25 mg per week). Conclusions Testing for TPMT ideally should be performed in every patient commencing a thiopurine drug.

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收藏

页码：473 / 476

页数：4

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