Mitochondrial toxin 3-nitropropionic acid produces startle reflex abnormalities and striatal damage in rats that model some features of Huntington's disease

被引：54

作者：

Kodsi, MH ^{[1
]}

Swerdlow, NR ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT PSYCHIAT,LA JOLLA,CA 92093

来源：

NEUROSCIENCE LETTERS | 1997年 / 231卷 / 02期

关键词：

sensorimotor gating; prepulse inhibition; mitochondrial toxin; 3-nitropropionic acid; neurotoxin;

D O I：

10.1016/S0304-3940(97)00482-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Systemic administration of the mitochondrial toxin 3-nitropropionic acid (3NP) to rats produces striatal lesions that mimic some aspects of pathology in Huntington's disease (HD). To evaluate whether 3NP-induced lesions cause sensorimotor gating deficits observed in HD, we measured prepulse inhibition (PPI) of the acoustic startle reflex after systemic administration of 3NP (10, 15, or 20 mg/kg) to 5-month-old rats. PPI, the reduction of startle magnitude by a weak auditory prestimulus, is significantly reduced in patients with HD. Two daily injections of 3NP produced gross histologic evidence of striatal lesions in some rats and significantly reduced PPI. Striatal lesions also significantly disrupted amphetamine-induced stereotypy, another index of dorsal striatal function. 3NP thus reproduces a specific objective and quantifiable gating deficit found in patients with HD. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：103 / 107

页数：5

共 29 条

[21]

Palfi SP, 1996, J NEUROSCI, V16, P3019

[22] EVIDENCE FOR A DEFECT IN NADH - UBIQUINONE OXIDOREDUCTASE (COMPLEX-I) IN HUNTINGTONS-DISEASE [J].

PARKER, WD ;

BOYSON, SJ ;

LUDER, AS ;

PARKS, JK .

NEUROLOGY, 1990, 40 (08) :1231-1234

[23]

Paxinos G., 1986, RAT BRAIN STEREOTAXI, P119

[24]

PERRY W, 1994, AM J PSYCHIAT, V151, P363

[25] MITOCHONDRIAL DYSFUNCTION IN MOVEMENT-DISORDERS [J].

SCHULZ, JB ;

BEAL, MF .

CURRENT OPINION IN NEUROLOGY, 1994, 7 (04) :333-339

[26]

Swerdlow N.R., 1996, ADV BIOL PSYCH, V2, P179

[27] IMPAIRED PREPULSE INHIBITION OF ACOUSTIC AND TACTILE STARTLE RESPONSE IN PATIENTS WITH HUNTINGTONS-DISEASE [J].

SWERDLOW, NR ;

PAULSEN, J ;

BRAFF, DL ;

BUTTERS, N ;

GEYER, MA ;

SWENSON, MR .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1995, 58 (02) :192-200

[28] A PRELIMINARY ASSESSMENT OF SENSORIMOTOR GATING IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER [J].

SWERDLOW, NR ;

BENBOW, CH ;

ZISOOK, S ;

GEYER, MA ;

BRAFF, DL .

BIOLOGICAL PSYCHIATRY, 1993, 33 (04) :298-301

[29]

WULLNER U, 1994, J NEUROCHEM, V63, P1772

← 1 2 3 →