Notch signaling: An emerging therapeutic target for cancer treatment

被引：407

作者：

Yuan, Xun ^{[1
]}

Wu, Hua ^{[1
]}

Xu, Hanxiao ^{[1
]}

Xiong, Huihua ^{[1
]}

Chu, Qian ^{[1
]}

Yu, Shiying ^{[1
]}

Wu, Gen Sheng ^{[2
,3
]}

Wu, Kongming ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan 430030, Peoples R China

[2] Wayne State Univ, Sch Med, Karmanos Canc Inst, Dept Oncol, Detroit, MI 48201 USA

[3] Wayne State Univ, Sch Med, Karmanos Canc Inst, Dept Pathol, Detroit, MI 48201 USA

来源：

CANCER LETTERS | 2015年 / 369卷 / 01期

关键词：

Notch signaling; Clinical trials; gamma-Secretase inhibitor; Targeted therapy; GAMMA-SECRETASE INHIBITOR; T-CELL LEUKEMIA; STEM-LIKE CELLS; PHASE-I; SOLID TUMORS; DOWN-REGULATION; PROTEASOME INHIBITION; SELF-RENEWAL; RO4929097; COMBINATION;

D O I：

10.1016/j.canlet.2015.07.048

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch signaling pathway is one of the most commonly activated signaling pathways in cancer. Alterations include activating mutations and amplification of the Notch pathway, which play key roles in the progression of cancer. Accumulating evidence suggests that the pharmacological inhibition of this pathway can overcome chemoresistance. Efforts have been taken to develop Notch inhibitors as a single agent or in combination. with clinically used chemotherapeutics to treat cancer. Some Notch inhibitors have been demonstrated to have therapeutic efficacy in preclinical studies. This review summarizes the recent studies and clinical evaluations of the Notch inhibitors in cancer. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgfficensesiby-nc-nd/4.0/).

引用

收藏

页码：20 / 27

页数：8

相关论文

共 90 条

[1]

Ahmad Aamir, 2012, Front Biosci (Elite Ed), V4, P410

[2]

Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma [J].

Allen, Thaddeus D. ;

Rodriguez, Elena M. ;

Jones, Kirk D. ;

Bishop, J. Michael .

CANCER RESEARCH, 2011, 71 (18) :6010-6018

[3]

Therapeutic modulation of Notch signalling - are we there yet? [J].

Andersson, Emma R. ;

Lendahl, Urban .

NATURE REVIEWS DRUG DISCOVERY, 2014, 13 (05) :359-380

[4]

EGFR Blockade Enriches for Lung Cancer Stem-like Cells through Notch3-Dependent Signaling [J].

Arasada, Rajeswara Rao ;

Amann, Joseph M. ;

Rahman, Mohammad A. ;

Huppert, Stacey S. ;

Carbone, David P. .

CANCER RESEARCH, 2014, 74 (19) :5572-5584

[5]

Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model [J].

Arcaroli, J. J. ;

Quackenbush, K. S. ;

Purkey, A. ;

Powell, R. W. ;

Pitts, T. M. ;

Bagby, S. ;

Tan, A. C. ;

Cross, B. ;

McPhillips, K. ;

Song, E-K ;

Tai, W. M. ;

Winn, R. A. ;

Bikkavilli, K. ;

VanScoyk, M. ;

Eckhardt, S. G. ;

Messersmith, W. A. .

BRITISH JOURNAL OF CANCER, 2013, 109 (03) :667-675

[6]

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses [J].

Azzam, Diana J. ;

Zhao, Dekuang ;

Sun, Jun ;

Minn, Andy J. ;

Ranganathan, Prathibha ;

Drews-Elger, Katherine ;

Han, Xiaoqing ;

Picon-Ruiz, Manuel ;

Gilbert, Candace A. ;

Wander, Seth A. ;

Capobianco, Anthony J. ;

El-Ashry, Dorraya ;

Slingerland, Joyce M. .

EMBO MOLECULAR MEDICINE, 2013, 5 (10) :1502-1522

[7]

Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma [J].

Ban, Jozef ;

Aryee, Dave N. T. ;

Fourtouna, Argyro ;

van der Ent, Wietske ;

Kauer, Max ;

Niedan, Stephan ;

Machado, Isidro ;

Rodriguez-Galindo, Carlos ;

Tirado, Oscar M. ;

Schwentner, Raphaela ;

Picci, Piero ;

Flanagan, Adrienne M. ;

Berg, Verena ;

Strauss, Sandra J. ;

Scotlandi, Katia ;

Lawlor, Elizabeth R. ;

Snaar-Jagalska, Ewa ;

Llombart-Bosch, Antonio ;

Kovar, Heinrich .

CANCER RESEARCH, 2014, 74 (22) :6578-6588

[8]

The Notch signaling pathway as a mediator of tumor survival [J].

Capaccione, Kathleen M. ;

Pine, Sharon R. .

CARCINOGENESIS, 2013, 34 (07) :1420-1430

[9]

Chang ACY, 2014, DEV DYNAM, V243, P894, DOI [10.1002/dvdy.24127, 10.1002/DVDY.24127]

[10]

The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma [J].

Chanh Huynh ;

Poliseno, Laura ;

Segura, Miguel F. ;

Medicherla, Ratna ;

Haimovic, Adele ;

Menendez, Silvia ;

Shang, Shulian ;

Pavlick, Anna ;

Shao, Yongzhao ;

Darvishian, Farbod ;

Boylan, John F. ;

Osman, Iman ;

Hernando, Eva .

PLOS ONE, 2011, 6 (09)

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