The cancer epigenome: Concepts, challenges, and therapeutic opportunities

被引：346

作者：

Dawson, Mark A. ^{[1
,2
,3
,4
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Res Div, Melbourne, Vic, Australia

[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[3] Univ Melbourne, Ctr Canc Res, Melbourne, Vic, Australia

[4] Peter MacCallum Canc Ctr, Dept Haematol, Melbourne, Vic, Australia

来源：

SCIENCE | 2017年 / 355卷 / 6330期

基金：

英国医学研究理事会;

关键词：

TERT PROMOTER MUTATIONS; ACUTE MYELOID-LEUKEMIA; STEM-CELLS; MYELODYSPLASTIC SYNDROME; SELECTIVE-INHIBITION; CLONAL HEMATOPOIESIS; HISTONE METHYLATION; CBX FAMILY; RESISTANCE; PLASTICITY;

D O I：

10.1126/science.aam7304

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Cancer biology is profoundly influenced by changes in the epigenome. Because the dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past few years have witnessed an unprecedented investment in the development, characterization, and translation of targeted epigenetic therapies. In this review, I provide a broad context for recent developments that offer a greater understanding of how epigenetic regulators facilitate the initiation, maintenance, and evolution of cancer. I discuss newly developed epigenetic therapies and the cellular and molecular mechanisms that may govern sensitivity and resistance to these agents. I also review the rationale for future combination therapies involving existing and emerging epigenetic drugs.

引用

页码：1147 / 1152

页数：6

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